SS-31 (also known as Bendavia or Elamipretide) is a synthetic tetrapeptide with the sequence D-Arg-dimethylTyr-Lys-Phe-NH2. With the molecular formula C₃₂H₄₉N₉O₅ and a molecular weight of 639.8 g/mol (CAS: 736992-21-5), SS-31 is a mitochondria-targeted peptide with antioxidant properties.
D-Arg-2,6-dimethylTyr-Lys-Phe-NH2Zhao et al. (2012) characterized SS-31's binding to cardiolipin and its effects on mitochondrial membrane potential in vitro (PMID: 22885605).
PMID: 22885605VERIFY PMIDZhao et al. (2014) investigated SS-31's mechanism of action at the mitochondrial inner membrane and electron transport chain (PMID: 25389201).
PMID: 25389201VERIFY PMIDSS-31 binds specifically to cardiolipin at the mitochondrial inner membrane, stabilizing electron transport complexes in vitro (PMID: 22885605).
Research indicates SS-31 reduces mitochondrial ROS production and protects cardiolipin oxidation in cell cultures (PMID: 25389201).
All compounds are sold strictly for laboratory research use. Not for human or animal consumption. These products are not drugs, supplements, or food. Statements have not been evaluated by the FDA. Must be 21+ to purchase. This compound is intended exclusively for in vitro laboratory research. Not for human or veterinary use. Not intended to diagnose, treat, cure, or prevent any disease.
