MOTS-c (Mitochondrial Open Reading Frame of the Twelve S rRNA-c) is a synthetic 16-amino acid peptide encoded in the mitochondrial genome. With the molecular formula C₁₀₁H₁₅₂N₂₈O₂₂S₂ and a molecular weight of 2174.6 g/mol (CAS: 1627580-64-6), MOTS-c represents a unique mitochondrial-derived peptide with metabolic regulatory functions.
MRWQEMGYIFYPRKLRLee et al. (2015) discovered MOTS-c and characterized its role in metabolic regulation and AMPK activation in skeletal muscle cells (PMID: 26546794).
PMID: 26546794VERIFY PMIDReynolds et al. (2016) investigated MOTS-c's effects on FGF21 expression and metabolic signaling in adipocyte cultures (PMID: 27304508).
PMID: 27304508VERIFY PMIDMOTS-c activates AMPK signaling, influencing cellular energy metabolism in muscle and fat cell models (PMID: 26546794).
Research indicates MOTS-c increases FGF21 expression, affecting metabolic gene networks in adipose tissue cultures (PMID: 27304508).
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