NAD+ (Nicotinamide Adenine Dinucleotide) is a dinucleotide coenzyme composed of nicotinamide and adenine connected via phosphate groups. With the molecular formula C₂₁H₂₇N₇O₁₄P₂ and a molecular weight of 663.4 g/mol (CAS: 53-84-9), NAD+ is an essential electron carrier in cellular metabolism.
N/A (Non-peptide compound)Imai et al. (2013) characterized NAD+ as a substrate for sirtuin deacetylases and its role in metabolic regulation in vitro (PMID: 23295476).
PMID: 23295476VERIFY PMIDRajman et al. (2018) reviewed NAD+-dependent enzymatic pathways including sirtuins, PARPs, and CD38 in cellular models (PMID: 29388144).
PMID: 29388144VERIFY PMIDNAD+ serves as a coenzyme for sirtuin deacetylases, regulating protein acetylation status in metabolic pathways (PMID: 23295476).
As a redox cofactor, NAD+ cycles between oxidized and reduced states in glycolysis, TCA cycle, and oxidative phosphorylation (PMID: 29388144).
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