DSIP (Delta Sleep-Inducing Peptide) is a synthetic nonapeptide originally isolated from cerebral venous blood. With the molecular formula C₃₅H₄₈N₁₀O₁₅ and a molecular weight of 848.9 g/mol (CAS: 62568-57-4), DSIP consists of nine amino acids: Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu.
Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-GluSchoenen et al. (1980) characterized DSIP's structure and its interactions with sleep-regulating neurotransmitter systems in vitro (PMID: 6993080).
PMID: 6993080VERIFY PMIDDSIP interacts with GABA-B and NMDA receptor systems, modulating excitatory/inhibitory balance in neuronal cultures (PMID: 6993080).
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